ULTIMATE JOINT AND TENDON SUPPORT
Ultimate Joint Support
By combining cutting-edge pharmaceutical-grade ingredients with tried-and-tested high-quality herbal extracts, new Achilles from Antaeus Labs brings you the most advanced joint-support formula on the market!
Every hero has a weakness. For many weightlifters and bodybuilders this is their joints. Tendons and ligaments bear the brunt of punishing weight-lifting sessions, commonly becoming inflamed and sore.
The connective tissue just can’t keep up with the heavier and heavier weights lifted week after week.
Niggling pains become chronic injuries, often requiring a forced rest, a change of routine or the permanent dropping of some exercises altogether.
40 years of scientific research has established Palmitoylethanolamide (PEA) as one of the most important endogenous painkilling and anti-inflammatory compounds.
The naturally occurring fatty acid amide palmitoylethanolamide is an agonist of the peroxisome proliferator-activated receptor alpha (PPAR-α).  PPAR-α agonists have been shown to be effective for both acute and chronic pain. 
PEA can modulate pain sensitivity (nociception) by regulating mast cells.  Mast cells release bioactive mediators like histamine (that dilates blood vessels leading to swelling, redness, and warmth ) and nerve growth factor (that produces inflammation and sensitization of pain-sensing neurons ).
Brazilian traditional medicine uses H. aphrodisiaca for, among other things, muscle and bone weakness – use that has been borne out recently when a study found that H. aphrodisiaca-treated trained rats had stronger tendons that could take a bigger load and more stress than untreated trained rats. 
“H. aphrodisiaca associated with endurance training contributed to more efficient remodeling of the extracellular matrix, resulting in more resistant tendons to support high loads from intense muscle contraction. These findings suggest that H. aphrodisiaca infusion is a potential aid to optimize tendon remodeling in athletes.” 
The plant Xi Xian Cao (Siegesbeckia orientalis) has been used for centuries in traditional chinese medicine (TCM) for its anti-inflammatory properties. One constituent of Siegesbeckia is Kirenol – which has recently been discovered to be a potent anti-inflammatory that also suppressed joint inflammation and inhibited cartilage and bone destruction in a rat model of arthritis. 
Asthisamharaka (Cissus Quadrangularis) is another herb that has been used for centuries in Ayurvedic medicine to heal broken bones and injured ligaments and tendons.  Numerous studies show that Cissus is anti-osteoporotic and pro-osteogenic, and it’s long been a staple in the arsenal of athletes and bodybuilders with joint problems. 
“There was shortening of about two weeks in the duration of bone healing. The hastening in the fracture healing was attributed to the stimulation of all cells of mesenchymal origin, namely, the fibroblasts, chondroblasts and osteoblasts, by Cissus quandrangularis.” 
Zingiber Zerumbet is a species of ginger, the rhizome (root) of which has been used traditionally throughout Southeast Asia to treat pain and inflammation. Recent studies have demonstrated antinociceptive, anti-inflammatory, and antioxidant properties.  In addition to containing molecules such as 6-gingerol, which are very well-known anti-inflammatory modulators, some of the phytochemical constituents that make up Zingiber Zerumbet have been found to be potent histone deacetylase (HDAC) inhibitors.  Several studies have recently concluded that HDAC inhibition can reduce joint inflammation and protect cartilage. 
“In conclusion, inhibition of HDAC prevents joint inflammation and cartilage and bone destruction in experimental arthritis.” 
“HDAC inhibitors may therefore be novel chondroprotective therapeutic agents in arthritis by virtue of their ability to inhibit the expression of destructive metalloproteinases by chondrocytes.” 
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
 Verme JL, Fu J, Astarita G, Rana GL, Russo R, Calignano A, et al. The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide. Mol Pharmacol. 2005 Jan 1;67(1):15–9.
 Fehrenbacher JC, Loverme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. Rapid pain modulation with nuclear receptor ligands. Brain Res Rev. 2009 Apr;60(1):114–24.
 Mazzari S, Canella R, Petrelli L, Marcolongo G, Leon A. N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation. Eur. J. Pharmacol. 1996 Apr 11;300(3):227–36.
 Prussin C, Metcalfe DD. 4. IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol. 2003 Feb;111(2 Suppl):S486–494.
 Nicol GD, Vasko MR. Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks? Mol. Interv. 2007 Feb;7(1):26–41.
 Monteiro JC, Gomes ML, Tomiosso TC, Nakagaki WR, Sbervelheri MM, Ferrucci DL, et al. More resistant tendons obtained from the association of Heteropterys aphrodisiaca and endurance training. BMC Complementary and Alternative Medicine. 2011 Jun 28;11(1):51.
 Lu Y, Xiao J, Wu Z-W, Wang Z-M, Hu J, Fu H-Z, et al. Kirenol exerts a potent anti-arthritic effect in collagen-induced arthritis by modifying the T cells balance. Phytomedicine. 2012 Jul 15;19(10):882–9.
 Wang Z-M, Zhu S-G, Wu Z-W, Lu Y, Fu H-Z, Qian R-Q. Kirenol upregulates nuclear annexin-1 which interacts with NF-κB to attenuate synovial inflammation of collagen-induced arthritis in rats. J Ethnopharmacol. 2011 Sep 1;137(1):774–82.
 Upadhya V, Hegde HV, Bhat S, Hurkadale PJ, Kholkute SD, Hegde GR. Ethnomedicinal plants used to treat bone fracture from North-Central Western Ghats of India. J Ethnopharmacol. 2012 Jul 13;142(2):557–62.
 Singh V, Singh N, Pal US, Dhasmana S, Mohammad S, Singh N. Clinical evaluation of cissus quadrangularis and moringa oleifera and osteoseal as osteogenic agents in mandibular fracture. Natl J Maxillofac Surg. 2011;2(2):132–6.
 Aswar UM, Mohan V, Bodhankar SL. Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats. Indian J Pharmacol. 2012;44(3):345–50.
 Yob NJ, Jofrry SM, Affandi MMRMM, Teh LK, Salleh MZ, Zakaria ZA. Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. Evid Based Complement Alternat Med [Internet]. 2011.
 Chung I-M, Kim M-Y, Park W-H, Moon H-I. Histone deacetylase inhibitors from the rhizomes of Zingiber zerumbet. Pharmazie. 2008 Oct;63(10):774–6.
 Joosten LA, Leoni F, Meghji S, Mascagni P. Inhibition of HDAC Activity by ITF2357 Ameliorates Joint Inflammation and Prevents Cartilage and Bone Destruction in Experimental Arthritis. Mol Med. 2011;17(5-6):391–6.
 Young DA, Lakey RL, Pennington CJ, Jones D, Kevorkian L, Edwards DR, et al. Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Res Ther. 2005;7(3):R503–R512.
 Chen W-P, Bao J-P, Hu P-F, Feng J, Wu L-D. Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. Mol. Biol. Rep. 2010 Dec;37(8):3967–72.